Status:
RECRUITING
Natural History of Coronary Atherosclerosis
Lead Sponsor:
China National Center for Cardiovascular Diseases
Conditions:
Coronary Artery Disease Progression
Radial Wall Strain
Eligibility:
All Genders
18+ years
Brief Summary
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed ...
Detailed Description
The recently developed angiography-derived maximum RWS (RWSmax) was computed as the maximum deformation of lumen diameter throughout the cardiac cycle, expressed as a percentage of the largest lumen d...
Eligibility Criteria
Inclusion
- General
- Age ≥18 years
- Acute myocardial infarction ≤ 45 days
- Planned coronary angiography examination or potential interventional treatment
- Angiographic
- The presence of at least 1 non-flow-restricting lesion (visually estimated diameter stenosis: 30%-80%; QFR \> 0.80) in any non-infarct related artery with RVD ≥2.5 mm by visual assessment
Exclusion
- General exclusion Criteria:
- Cardiogenic shock
- Pregnant or woman of child-bearing potential
- Life expectancy less than 1 year for non-cardiac causes
- Unable to tolerate contrast agents or anticoagulant/antiplatelet therapy
- Prior CABG or planned CABG
- Angiographic exclusion Criteria:
- Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to QFR or RWS measurement
- An interrogated lesion require surgical bypass grafting
- Unable to judge culprit lesion or infarct-related artery according to current evidence
Key Trial Info
Start Date :
July 7 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT06040073
Start Date
July 7 2024
End Date
December 31 2026
Last Update
November 6 2024
Active Locations (1)
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1
Lei Song
Beijing, China, 100037