Status:
RECRUITING
Investigation of Locus Coeruleus Function in Sustained Attention
Lead Sponsor:
University of California, Davis
Conditions:
Attention - no Condition is Being Assessed - Healthy Adults
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including at...
Detailed Description
Attention failures negatively impact goal pursuit and have significant consequences on performance in many environments. Attentional control of perceptual, motor and cognitive functions are believed t...
Eligibility Criteria
Inclusion
- Between the ages of 18 - 60 years of age,
- Typically developing, healthy adult
Exclusion
- History of schizophrenia, other forms of psychosis,
- Specific or focal neurological disorder or severe alcohol or drug use disorder within the past 5 years
- History of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants, or who have had recent history of myocardial infarction or unstable angina.
- Volunteers with known hypersensitivity to modafinil or armodafinil or its inactive ingredients
- Known allergy/sensitivity or any hypersensitivity to components of modafinil or its formulation
- Inability to swallow tablets or tolerate oral medication;
- Pregnant or nursing (participants will be required to have a negative pregnancy test)
- Contraindication for MRI scanning (metal implants, pacemakers, metal foreign bodies, or pregnancy)
- Use of psychotropic medication within the past week
- Claustrophobic and not comfortable being in a small space may also not want to participate
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06041048
Start Date
October 1 2023
End Date
December 30 2025
Last Update
December 12 2025
Active Locations (1)
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1
University of California, Davis
Sacramento, California, United States, 95817