Status:
COMPLETED
Agaricus Bisporus and Influenza Vaccination Response
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Scelta Mycofriends B.V.
CNC Grondstoffen B.V.
Conditions:
Immune Response
Eligibility:
All Genders
59+ years
Phase:
NA
Brief Summary
There are numerous in vitro and animal studies that suggested that mushrooms beneficially influence the immune system. We have recently shown that a wild isolate of the edible Agaricus bisporus mushro...
Eligibility Criteria
Inclusion
- Aged 60 years or older during influenza season 2023/2024 (in line with RIVM guidelines)
- BMI between 20 and 35 kg/m2
- Willing to abstain from mushrooms other than the capsules containing a mushroom powder as provided by us during the study period.
- Willing to keep the intake of fish oil, Zinc, Selenium and (vitamin) supplements constant
- Willing to abstain from products / supplements enriched with Vitamin D
- Willing to abstain from products / supplements enriched with plant sterols or stanols
- Willing to abstain from products / supplements enriched with (β)glucans or fungi.
- Willing to abstain from products / supplements that are mentioned to "boost your immune system"
- Willing to abstain from (products enriched in) pre/pro-biotics
- Willing to abstain from products/supplements enriched with ergothioneine
Exclusion
- Already received influenza vaccination in 2023
- Allergy to mushrooms
- Known allergic reaction to an active component or other components of the vaccine (e.g. Chicken Eggs)
- Having donated blood within one month prior to the start of the study, or planning to donate blood during the study
- Excessive alcohol use (\>20 consumptions per week)
- Regular use of soft and/or hard drugs
- Using medication for diseases known to affect inflammation/immunity (e.g. inhaled corticosteroids and prednisone)
Key Trial Info
Start Date :
September 14 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2024
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT06041867
Start Date
September 14 2023
End Date
May 30 2024
Last Update
March 24 2025
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6229 ER