Status:
RECRUITING
DIALYSIS-TIR Study
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
University of North Carolina, Chapel Hill
Conditions:
Type 2 Diabetes
End Stage Renal Disease on Dialysis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide t...
Detailed Description
The researchers also have a Data Safety Monitoring Plan in place.
Eligibility Criteria
Inclusion
- Ability to provide informed consent before any trial-related activities. Trial-related activities are any procedures that are carried out as a part of trial, including activities to determine suitability for the trial.
- Male or female Adults (age \> 18 years at the time of signing the consent)
- Type 2 diabetes mellitus diagnosed \> 6 months prior to screening
- On current chronic treatment with Hemodialysis or Peritoneal dialysis for \> 6 months prior to screening
- Current treatment with any glucose lowering pharmacotherapy, at a stable dose for at least 30 days. DPP-4 Inhibitors will be allowed at study entry and will be stopped at randomization.
- Minimum of 80% valid data on the 10-day Continuous Glucose Monitor download
- Time in Range 15 to 60%
Exclusion
- BMI \< 23 kg/m2 at screening
- Current (within the past 90 days of screening) use of any GLP-1 RA
- Personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia type 2
- Known or suspected hypersensitivity to GLP-1 RA (trial medication(s), excipients, or related products)
- Pregnant, breast-feeding or the intention of becoming pregnant, or not using effective contraceptive measures
- Active weight loss, defined as weight loss of \>5% of body weight in the past 3 months
- Current participation in other interventional trials or last dose of any investigational product within 4 half- lives at the time of randomization
- Any medical condition which in the judgement of the investigator precludes safe participation in the trial (includes, but not limited to active neoplasm, severe heart failure, recent cardiovascular event, severe frailty, planned cardiac or vascular surgeries on the day of screening etc)
- If weight loss is not desired by the participant, or if the provider or investigator considers intentional weight loss to be detrimental to the health of the participant
- Other or secondary forms of diabetes (like type 1 diabetes, pancreatogenic diabetes mellitus, MODY, LADA, drug induced, etc.)
- Current diagnosis of gastroparesis or enteropathywhich in the opinion of investigator precludes safe treatment with GLP-1 RA.
- Hypoglycaemia unawareness, or history of frequent or severe hypoglycaemia (in the opinion of the investigator)
- Personal history of chronic pancreatitis, or acute pancreatitis within 180 days of screening
- Known current uncontrolled or unstable retinopathy (by medical history)
Key Trial Info
Start Date :
December 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2028
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT06042153
Start Date
December 5 2023
End Date
September 1 2028
Last Update
February 14 2025
Active Locations (5)
Enter a location and click search to find clinical trials sorted by distance.
1
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
2
Davita UT Southwestern - Oak Cliff
Dallas, Texas, United States, 75224
3
DaVita UT Southwestern - East Dallas
Dallas, Texas, United States, 75228
4
DaVita UT Southwestern - Preston
Dallas, Texas, United States, 75240