Status:
UNKNOWN
Cognitive Impairment and Fatigue After Mild to Moderate COVID-19
Lead Sponsor:
Danderyd Hospital
Collaborating Sponsors:
Karolinska Institutet
Karolinska University Hospital
Conditions:
Post COVID-19 Condition
Cognitive Impairment
Eligibility:
All Genders
18-65 years
Brief Summary
The primary aim of the project is to map fatigue, cognitive and visual dysfunctions and possible underlying pathophysiological mechanisms in persons with long-term symptoms after a mild to moderate CO...
Detailed Description
The primary aim of the project is to map neuropsychological and visual dysfunctions and possible underlying pathophysiological mechanisms in patients suffering from Post-COVID condition (PCC) after a ...
Eligibility Criteria
Inclusion
- • Persons 18 years and older with a history of (\> 3 months) verified COVID-19 (PCR / rapid test / antibody) or an infection that is most likely a SARS-CoV-2 infection (e.g., a close relative had a verified infection that coincided in time with the patient's illness) and who have persistent problems with cognitive impairment or fatigue affecting the return to previous activities / employment.
Exclusion
- Dominant recurrent and / or fluctuating symptoms of infection, circulatory, respiratory or cardiac problems.
- Co-morbidities that may cause cognitive impairment such as neurodegenerative disease, substance abuse, severe mental illness (eg. schizophrenia, mano depressive disorder) or severe depression.
- Not fluent in Swedish, as test and self-reports rely on good mastering of the Swedish language.
- Severe premorbid visual impairment.
- Additionally for the fMRI study:
- Not verified SARS-CoV-2 infection with a Polymerase Chain Reaction (PCR) / rapid test / antibody review
- Traumatic brain injury
- Neuropsychiatric disease such as diagnosed ADHD or autism
- Younger than 25 years or older than 55 years (to avoid the risk that the brain is not fully developed or that there is a risk of age-related changes in the brain).
- MRI contraindications (such as metal objects in the body, fear of cramped spaces, pregnancy, body weight over 130 kg), and left-handedness (to increase the likelihood of uniform topological lateralization in the cohort).
Key Trial Info
Start Date :
April 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06042530
Start Date
April 1 2021
End Date
December 31 2025
Last Update
September 21 2023
Active Locations (1)
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1
Department of Rehabilitation Medicine, Danderyd Hospital
Stockholm, Sweden, 18288