Status:
COMPLETED
Characteristics of Cytokine Response in Patients With Temporomandibular Disorders Treated With Occlusal Splint Therapy
Lead Sponsor:
Josip Juraj Strossmayer University of Osijek
Conditions:
Temporomandibular Joint Disorders
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The goal of this intervention study is to determine the effect of occlusal splint (OS) therapy on the concentration of inflammatory cytokines in serum and gingival crevicular fluid (GCF) in patients w...
Detailed Description
Temporomandibular disorder (TMD) is a multifactorial disease with complex etiopathogenesis. The main symptoms are persistent pain in the masticatory muscles and preauricular region, limitations in jaw...
Eligibility Criteria
Inclusion
- signed informed consent
- TMP pain screening scores ≥ 3
- patients with natural teeth
- diagnoses: myalgia, arthralgia, headache attributed to TMP and painful disc displacement (with and without reduction) according to axis I diagnostic criteria for temporomandibular disorders (DK/TMP)
Exclusion
- degenerative joint disease and subluxation of the temporomandibular joint (TMJ)
- head trauma
- orofacial pain not associated with temporomandibular disorders
- patients with fixed or removable prostheses
- patients who are currently undergoing orthodontic therapy and/or using occlusal splints
- patients who used anti-inflammatory drugs and muscle relaxants 48 hours before data collection, and patients who use drugs with an impact on the immune system (such as antiproliferative immunosuppressants, corticosteroids and other immunosuppressants, antirheumatic drugs, DMARDs, anti-lymphocyte monoclonal antibodies and other immunomodulating drugs , antidepressants, antiepileptics)
- periodontitis
- pregnancy
Key Trial Info
Start Date :
August 16 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 16 2024
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06043024
Start Date
August 16 2023
End Date
August 16 2024
Last Update
September 19 2024
Active Locations (1)
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1
Helath Center Osijek-Baranja county
Osijek, County of Osijek-Baranja, Croatia, 31 000