Status:
NOT_YET_RECRUITING
Outcome Prediction in Patients With Aortic Stenosis After TAVI
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Aortic Stenosis, Severe
Eligibility:
All Genders
18+ years
Brief Summary
This study will investigate changes right ventricular function and functional recovery metrics after transcatheter aortic valve implantation
Detailed Description
Aortic stenosis (AS), is a condition in which the aortic valve becomes narrowed as people get older, causing the heart pump (the left ventricle) to struggle to push blood through it, leading to breath...
Eligibility Criteria
Inclusion
- Patients with symptomatic severe aortic stenosis (AVA \<1.0 cm2/\<0.6cm2/m2 or mean gradient \>40mmHg or jet velocity \>4.0 m/s).
Exclusion
- Extracardiac limitations of ambulatory exercise, cardiac rehab opt out, non-transfemoral TAVI, haemodynamic instability/cardiogenic shock, LVEF \<40%, poorly controlled AF, severe COPD, primary pulmonary hypertension, evidence of cardiac amyloid, more than moderate concomitant valvular heart disease other than aortic stenosis, previous sternotomy, permanent pacemaker implant, patients enrolled in another study where participation would involve deviation from either protocol.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT06043180
Start Date
October 1 2023
End Date
February 1 2027
Last Update
September 21 2023
Active Locations (1)
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1
Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital
London, United Kingdom