Status:
ACTIVE_NOT_RECRUITING
Estrogen and Microvascular Function
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Estrogen
Cardiovascular Diseases
Eligibility:
FEMALE
18-40 years
Brief Summary
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: * give one blood draw of 5 mL * have one Dexa Scan taken to measure adipo...
Eligibility Criteria
Inclusion
- Estrogen/Progestin Group
- Adults aged 18-40 years
- Females with estrogen/progestin treatment for a minimum of 1 year.
- Blood pressure \<140/ \< 90 mmHg
- No more than 1 cardiovascular risk factor Control Groups
- Adults aged 18-40 years
- Female with no estrogen/progestin treatment for minimum of 5 years.
- Female undergoing progestin only treatment for a minimum of 1 year.
- Blood pressure \<140/ \< 90 mmHg
- No more than 1 cardiovascular risk factor
Exclusion
- Medications that could alter cardiovascular control
- Rash, skin disease, or pigmentation disorders on both forearms
- Anemia
- Kidney Disease
- Known skin allergies
- Smoking or tobacco use within last 6 months
- Coronary Artery Disease
- 1 cardiovascular risk factor Hypertension Diabetes Hypercholesterolemia Hyperlipidemia
- Bleeding disorders
- Use of anti-coagulants
- Allergies to study drugs
- Use of topical/non-topical steroids in last 6 months
- Internal mouth sores
- Forearms covered with tattoos
- Pregnancy
Key Trial Info
Start Date :
October 12 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2031
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06043310
Start Date
October 12 2023
End Date
December 1 2031
Last Update
July 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Froedtert Hospital
Wauwatosa, Wisconsin, United States, 53226