Status:
ACTIVE_NOT_RECRUITING
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
Lead Sponsor:
Medical University of South Carolina
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Brief Summary
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people r...
Detailed Description
The purpose of this study is to take a picture of the participants brain using magnetic resonance imaging (MRI) and then use an investigational way of imaging the brain, called Individualized Network-...
Eligibility Criteria
Inclusion
- MDD volunteers:
- Inclusion Criteria
- Age 18-65
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- DSM-IV diagnosis of MDD
- Exclusion Criteria
- Unable to speak English.
- Contraindicated for MRI.
- Any current or recent untreated medical, neurological, or psychiatric conditions other than MDD that would preclude candidacy for TMS.
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of cortisol medication use or electroconvulsive therapy.
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal history of recent head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Individuals suffering from frequent/severe headaches.
- Moderate to severe alcohol or substance use disorder.
- Pregnancy
- Healthy Volunteers Inclusion Criteria
- Age 18-65
- Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
- Exclusion Criteria
- Unable to speak English.
- Contraindicated for MRI.
- Any current or recent untreated medical, neurological, or psychiatric conditions
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of cortisol medication use or electroconvulsive therapy.
- Comorbidity with other psychiatric/neurological illnesses or personality disorders
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal history of recent head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Individuals suffering from frequent/severe headaches.
- Moderate to severe alcohol or substance use disorder.
- Pregnancy
Exclusion
Key Trial Info
Start Date :
April 4 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06043401
Start Date
April 4 2023
End Date
April 1 2026
Last Update
April 29 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425