Status:
RECRUITING
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Lead Sponsor:
University Hospital, Rouen
Conditions:
Asthma in Children
Asthma
Eligibility:
All Genders
Up to 24 years
Phase:
NA
Brief Summary
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evo...
Eligibility Criteria
Inclusion
- Infants less than 24 months old
- Follow-up by a pneumo-pediatrician for severe asthma in infants
- Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
- Parent informed of the research and having signed consent
Exclusion
- Prematurity \<32 WA
- Congenital heart disease with significant left to right shunt
- Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
- Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
- Refusal of bronchial fibroscopy
Key Trial Info
Start Date :
September 26 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 26 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06044051
Start Date
September 26 2023
End Date
September 26 2026
Last Update
December 28 2023
Active Locations (1)
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1
Rouen University Hospital
Rouen, France