Status:
UNKNOWN
Brain Activity Under the Influence of JWH
Lead Sponsor:
Maastricht University
Conditions:
Neurotransmission During JWH Intoxication
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The goal of this placebo-controlled study is to learn about the neural mechanisms underlying the acute effects of the synthetical cannabinoid JWH-018 in healthy, occasional cannabis users. It aims to ...
Eligibility Criteria
Inclusion
- sufficient experience with cannabis
- Age between 18 and 40 years
- Free from psychotropic medication
- Good physical health
- Absence of any major medical, endocrine and neurological condition
- Normal weight, body mass index (weight/height\^2) between 18 and 28 kg/m\^2
- Written Informed Consent
- Good knowledge and understanding of the English language
- refrain from taking illicit psychoactive substances during the study
- willing to drink only alcohol-free liquids and no caffeinated beverages from 24 hours prior to dosing day, as well as during the study day
- Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.
Exclusion
- History of drug addiction
- Pregnancy or lactation or pregnancy planned during study participation
- Hypertension (diastolic \> 90 mmHg; systolic \> 140 mmHg)
- Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)
- Any chronic or acute medical condition
- History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…)
- For women: no use of a reliable contraceptive
- Tobacco smoking (\>20 per day)
- Excessive drinking (\>20 alcoholic consumptions per week)
- Simultaneous participation in another clinical trial
- fMRI contraindications
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06044415
Start Date
October 1 2023
End Date
October 1 2024
Last Update
September 21 2023
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