Status:
RECRUITING
EEG Microstates Across At-Risk Mental States
Lead Sponsor:
Centre Hospitalier St Anne
Collaborating Sponsors:
Assistance Publique - Hôpitaux de Paris
Conditions:
Psychotic Disorders
Autism Spectrum Disorder
Eligibility:
All Genders
15-30 years
Phase:
NA
Brief Summary
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). Th...
Detailed Description
* Aim of the study: EEG microstates translate the resting-state temporal dynamics of neuronal networks throughout the brain. Here, the investigators aim to see whether EEG microstate anomalies could c...
Eligibility Criteria
Inclusion
- age between 15 and 30 years
- subjects meeting CAARMS criteria for stage Ia or Ib mental states at risk (for stage Ia, mild or nonspecific symptoms of psychosis or severe mood disorder, and mild functional impairment; for stage Ib, moderate symptoms below intervention threshold and moderate functional impairment)
- subjects meeting any DSM-5 criteria associated with a first onset of psychotic symptoms (first episode psychosis)
- subjects satisfying DSM-5 criteria for depressive disorder
- subjects meeting DSM-5 criteria for autism spectrum disorder
- healthy control subjects recruited from the general population
Exclusion
- suicidal risk
- severe or non-stabilized somatic and neurological disorders
- epilepsy
- head trauma
- IQ below 70
- for healthy control subjects, a family history of psychosis is an exclusion criterion
- bipolar disorder
- obsessive-compulsive disorder
- substance use disorder, except for cannabis, tolerated up to 5 joints/day.
Key Trial Info
Start Date :
May 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2026
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT06045897
Start Date
May 30 2023
End Date
July 30 2026
Last Update
September 21 2023
Active Locations (1)
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1
Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences
Paris, France, 75014