Status:
RECRUITING
A Study of Contralateral Limb Block
Lead Sponsor:
Mayo Clinic
Conditions:
Limb Pain, Phantom
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralatera...
Eligibility Criteria
Inclusion
- Lower extremity amputation performed more than 12 months before study enrollment
- PLP/RLP in affected amputated limb \> 4 on NRS26
- Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis)
- Willingness to undergo image guided diagnostic nerve block
Exclusion
- Refusal / inability to participate or provide consent
- Contraindications to diagnostic nerve block
- Non-neurogenic source of PLP/RLP
- Current opioid use \> 50 morphine milligram equivalents per day
- Any interventional pain treatment in the residual limb within the last 30 days
- Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism)
- Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment
Key Trial Info
Start Date :
June 18 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06045936
Start Date
June 18 2024
End Date
December 1 2026
Last Update
January 6 2026
Active Locations (1)
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1
Mayo Clinic Health System - Mankato
Mankato, Minnesota, United States, 56001