Status:
NOT_YET_RECRUITING
Sepsis in Oncology Patients
Lead Sponsor:
Royal Marsden NHS Foundation Trust
Conditions:
Sepsis in Cancer Patients
Eligibility:
All Genders
18+ years
Brief Summary
The overall objective of this prospective observational study is to address the significant knowledge gap that exists around the impact of immune dysfunction on the development and survival from sepsi...
Detailed Description
The specific aims will be to perform multi-modal parallel immune phenotyping to determine: * The transcriptomic (RNA) phenotypes (or 'signatures') of cancer patients with sepsis * The association of ...
Eligibility Criteria
Inclusion
- Sepsis cohort:
- Patients admitted to ICU with a diagnosis of sepsis as per 'Sepsis-3' definitions with a SOFA score \[REF\] ≥2 secondary to infection from any source
- ≥18 years of age
- Written consent from patient, personal or professional consultee, or deferred consent if none of the above available at admission
- Sepsis cohort
Exclusion
- • Death deemed imminent by the clinical team
- Elective cohort inclusion criteria
- Patients undergoing elective major upper GI surgery (oesophago+/-gastrectomy) or stem cell transplant for haematological malignancy
- ≥18 years of age
- Written consent from patient
- Elective cohort exclusion criteria
- • Limitations in place regarding provision of treatment and/or organ support e.g., palliative patients
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT06046677
Start Date
September 1 2023
End Date
September 1 2027
Last Update
September 21 2023
Active Locations (1)
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1
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW36JJ