Status:
RECRUITING
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
Lead Sponsor:
University of Edinburgh
Conditions:
Aortic Stenosis
Eligibility:
All Genders
50+ years
Brief Summary
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement. Participants will un...
Detailed Description
This will be an observational cohort study using existing and prospectively recruited cohorts for both cross-sectional and longitudinal comparison across the spectrum of aortic stenosis severity. For ...
Eligibility Criteria
Inclusion
- Male or female aged \>50 years
- Provision of informed consent prior to any study specific procedures
- Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves
- Patients with severe aortic stenosis (peak velocity \>4.0 m/s; previously recruited patients)
- Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients)
- Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients)
- Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow)
- Age and sex-matched healthy volunteers
Exclusion
- Inability or unwilling to give informed consent.
- Those with an allergy to iodinated contrast
- Patients with impaired renal function (eGFR of \<30 mL/min/1.73m2)
- Women who are pregnant or breastfeeding.
- Patients with known Rheumatic Heart Disease
- Patients with known Ochronosis
- Patients with known Familial Homozygous Hypercholesterolaemia
Key Trial Info
Start Date :
May 22 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 22 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06047561
Start Date
May 22 2023
End Date
May 22 2028
Last Update
September 17 2025
Active Locations (1)
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1
University of Edinburgh
Edinburgh, United Kingdom, EH16 4SB