Status:
RECRUITING
UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
AML
ALL
Eligibility:
All Genders
4-75 years
Phase:
PHASE1
Brief Summary
Patients with graft failure or delayed engraftment may benefit from a hematopoietic stem cell boost or an additional hematopoietic stem cell transplantation procedure. In such settings standard immune...
Detailed Description
Patients eligible to be treated on this status are status post allogeneic hematopoietic stem cell transplantation for a neoplastic hematologic disorder with the need of a CD34 selected stem cell boost...
Eligibility Criteria
Inclusion
- AML in morphologic remission with intermediate/high-risk features or relapsed disease 1 or 2
- ALL in morphologic remission with high-risk features or relapsed disease 1 or 2
- Lymphoid malignancies in CR or PR (e.g. non-Hodgkin's lymphoma, prolymphocytic leukemia, CLL)
- Myelodysplastic syndromes with \<=10% blasts
- CML in morphologic remission after blast phase or accelerated phase
- Primary myelofibrosis with \<=10% blasts \^morphologic remission is defined as \<5% blasts on the bone marrow biopsy. Negative test for donor-specific antibody within 28 days of starting conditioning regimen, or adequate for standard desensitization protocol.
Exclusion
- Non-compliant patients.
- No appropriate caregivers identified.
- Uncontrolled medical or psychiatric disorders which may preclude patients to undergo clinical studies (Discretion of the attending physician).
- Patients with known allergy to DMSO.
- Pregnant or breastfeeding women
Key Trial Info
Start Date :
April 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2029
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06047886
Start Date
April 22 2025
End Date
December 1 2029
Last Update
April 24 2025
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294-3300