Status:
UNKNOWN
Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
Lead Sponsor:
Dr Ian B Wilkinson
Conditions:
Hypertension
Primary Aldosteronism
Eligibility:
All Genders
18-75 years
Brief Summary
This is an observational study compares the positivity rates of two tests for screening for primary aldosteronism: plasma aldosterone renin ratio and 24-hour urine aldosterone in patients with young-o...
Detailed Description
Plasma aldosterone and renin measurements are subject to significant intra-individual variability, including variation related to posture, time of day and sodium balance. Aldosterone secretion is not ...
Eligibility Criteria
Inclusion
- A patient will be eligible for inclusion in this trial only if all of the following criteria apply:
- Aged 18 years and above.
- Meets NICE criteria for a diagnosis of hypertension with an age of onset of hypertension between 18-60 years.
- For cohort 2 (suspected primary aldosteronism): resistant hypertension, and/or hypertension with spontaneous or diuretic-induced hypokalaemia, and/or hypertension.
Exclusion
- • Severe hypertension (sustained blood pressure of \>200/110 mmHg) or a history of known secondary hypertension other than PA.
- Contraindications to confirmatory testing with saline infusion or oral salt loading test as per standard clinical criteria such as known clinical diagnosis of heart failure, and/or chronic kidney disease stage 3b.
- Known Pregnancy or breast feeding.
- Lack of informed consent.
- Any medical condition deemed unsuitable by investigator for participation in the study
Key Trial Info
Start Date :
September 15 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06047912
Start Date
September 15 2023
End Date
December 30 2024
Last Update
September 21 2023
Active Locations (1)
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1
Vascular Research Clinic, Adenbrooke's Centre of Clinical Investigation, Addenbrooke's Hospital
Cambridge, United Kingdom