Status:
RECRUITING
Immunogenicity and Clinical Efficacy of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Lymphoma Survivors After Treatment With Anti-CD20 Therapy
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To compare the effects of a pneumococcal vaccine called PCV20 when given as a single dose versus a boosted regimen to patients who previously received anti-CD20 therapy as treatment for B cell lymphom...
Detailed Description
Primary Objectives: --Compare the humoral responses in terms of difference in IgG titers at 1 month from routine single dose PCV20 or a boosted PCV20 regimen in B cell lymphoma survivors who previous...
Eligibility Criteria
Inclusion
- Patients who have a history of non-Hodgkin B-cell lymphoma and whose disease has been in remission for at least 1 year.
- Patients who received any anti-CD20 therapy at any time during their treatment for B-cell lymphoma.
- Patients who are at least 18 years of age.
- Patients who can provide consent; no legal authorized representative will be able to provide consent on a patient's behalf.
Exclusion
- Patients who have received cellular therapy, including chimeric antigen receptor T-cell therapy or any type of hematopoietic cell transplantation.
- Patients who have received PCV or pneumococcal polysaccharide vaccine within 5 years of screening for enrollment.
- Patients who are unable to attend follow-up appointments at designated times at MD Anderson.
- Any vulnerable population patient ((children, pregnant women, cognitively impaired adults, or prisoners)
Key Trial Info
Start Date :
October 6 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06049134
Start Date
October 6 2023
End Date
August 1 2027
Last Update
August 8 2025
Active Locations (1)
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1
M D Anderson Cancer Center
Houston, Texas, United States, 77030