Status:

COMPLETED

The Characteristics of Backscattering With Depth in the Progression of Keratoconus

Lead Sponsor:

Tianjin Eye Hospital

Conditions:

Elasticum, Incomplete Pseudoxanthoma

Eligibility:

All Genders

Brief Summary

To investigate the variation in backscattering with depth between forme fruste keratoconus (FFKC), keratoconus, and normal eyes; to determine the backscattering changes in the characteristics of kerat...

Detailed Description

To investigate the variation in backscattering with depth between forme fruste keratoconus (FFKC), keratoconus, and normal eyes; to determine the backscattering changes in the characteristics of kerat...

Eligibility Criteria

Inclusion

  • BCVA \<20/20 and a history of myopia or astigmatism;
  • presence of any of the following positive signs on slit lamp examination: corneal stromal thinning, cone-shaped anterior protrusions, Fleischer's ring, Vogt's striae, epithelial or subepithelial scarring;
  • abnormal corneal topography (maximum keratometry (K) value of \>47.2 diopters (D), bow-tie pattern with skewed radial axes, or inferior-superior asymmetry(3-mm I-S keratometric difference \>1.4 D).

Exclusion

  • 1\. Patients with severe corneal scarring that affected light scattering and density maps showing "black holes" 2.Participatients with other corneal diseases 3. Eyes that have undergone surgery or trauma 4. Eyes with corneal dystrophy
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Key Trial Info

Start Date :

January 1 2020

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

December 30 2022

Estimated Enrollment :

223 Patients enrolled

Trial Details

Trial ID

NCT06050629

Start Date

January 1 2020

End Date

December 30 2022

Last Update

September 22 2023

Active Locations (1)

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Tianjin Eye Hospital

Tianjin, Tianjin Municipality, China