Status:
UNKNOWN
Effects of Platelet Mimicking Nanoparticles in Patients With Cirrhosis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Société Française d'Anesthésie et de Réanimation
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
18+ years
Brief Summary
Haemostasis of cirrhotic patients is disturbed at different levels: primary haemostasis, coagulation and fibrinolysis, leading to a new haemostatic balance. Thrombocytopenia and thrombopathy are count...
Detailed Description
Hepatic cirrhosis is accompanied by an alteration of the haemostatic balance (primary haemostasis, coagulation, fibrinolysis). With regard to primary haemostasis, thrombocytopenia is usually moderate,...
Eligibility Criteria
Inclusion
- Adult patients who are beneficiaries of a social security scheme or beneficiaries entitled to it
- Patients followed for a cirrhotic pathology at the Paul Brousse hospital and benefiting from a scheduled anaesthesia consultation for a scheduled interventional or surgical procedure
- For non-cirrhotic patients: adult patients who are beneficiaries of a social security scheme or beneficiaries entitled to it, benefiting from a blood test scheduled as part of their usual preoperative care (patients in the hepatology or digestive surgery department operated on at the Paul Brousse hospital)
Exclusion
- Patient not wishing to participate in the study
- Patient with a known haemostasis abnormality other than cirrhosis
- Patient on long-term antiplatelet or anticoagulant therapy
- Patient who has taken a non-steroidal anti-inflammatory drug within 5 days prior to the blood test
- Patients with thrombopathy of genetic origin
- Patient on estrogenic therapy
- Patient with cancer under treatment or treated in the last 6 months
- Patient on immunosuppressive or immunomodulatory therapy
Key Trial Info
Start Date :
October 15 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 15 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06050993
Start Date
October 15 2023
End Date
April 15 2024
Last Update
September 22 2023
Active Locations (1)
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1
Anaesthesia unit of the Hepatobiliary Center - Paul Brousse Hospital
Villejuif, France, 94800