Status:
RECRUITING
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Delirium, Postoperative
Cognitive Decline
Eligibility:
All Genders
70+ years
Brief Summary
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: ...
Detailed Description
This study is a prospective, observational study designed to identify changes in protein biomarkers levels as a function of delirium incidence and delirium severity scores based on Confusion Assessmen...
Eligibility Criteria
Inclusion
- Age \>= 70 years old
- Scheduled to undergo major orthopedic surgery
- Expected postoperative recovery of more than 24 hours as an inpatient
Exclusion
- Cognitive impairment leading to inability to consent
- Patients with limited mobility or inability to wear an actigraphy watch
- Patients with infection at the site of actigraphy watch, allergies to materials of watch
- Patients with \> two days in the ICU during the month prior to surgery
- Renal or liver failure
- Severe neurocognitive damage or history of psychiatric illness
- Blindness or deafness
- Patients who are non-English speaking
Key Trial Info
Start Date :
September 12 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06052397
Start Date
September 12 2023
End Date
September 1 2027
Last Update
November 12 2024
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114