Status:
ACTIVE_NOT_RECRUITING
A Study of Adipose Tissue in Adaptive Responses to Exercise
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Healthy
Obesity
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Detailed Description
Adipose tissue has important endocrine functions that influence metabolic health. Early evidence shows that adipose adapts to physiological stress, including exercise. The objective here is to determi...
Eligibility Criteria
Inclusion
- Adults between the ages of 18-35 OR 65-85.
- BMI 18.5 kg/m2 - 40 kg/m2
- Weight stable (≥ 3 months)
- Generally healthy
Exclusion
- Participation in ≥ 30 minutes of structured physical activity ≥ 2 days per week.
- Smoking/tobacco use.
- Alcohol/substance abuse.
- Pregnancy and breastfeeding.
- Anemia.
- Abnormal renal function.
- Blood clotting disorders.
- Coronary artery disease.
- Uncontrolled thyroid disease.
- Liver disease.
- Use of medications known to influence the main outcomes of the study.
- Orthopedic problems that may be aggravated by exercise.
- Chronic disease at the discretion of the investigators.
Key Trial Info
Start Date :
November 9 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2026
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06053125
Start Date
November 9 2023
End Date
October 1 2026
Last Update
October 23 2025
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905