Status:
RECRUITING
Mos-FED (Mosaicism in Focal Epilepsy Cortical Dysplasia Tissue)
Lead Sponsor:
King's College Hospital NHS Trust
Collaborating Sponsors:
King's College London
Danish Epilepsy Centre
Conditions:
Focal Cortical Dysplasia
Epilepsy
Eligibility:
All Genders
Phase:
NA
Brief Summary
Focal cortical dysplasia (FCD) is a malformation of brain development, the most common cause of drug-resistant epilepsy and often caused by mutations in mammalian target of rapamycin (mTOR) pathway ge...
Detailed Description
Primary Objectives: 1. To identify if somatic mosaicism for mTOR is present in resected tissue from patients with FCDIIA/B, and can be detected in DNA from patient's serum as circulating free DNA (cf...
Eligibility Criteria
Inclusion
- Epilepsy in Focal Cortical Dysplasia Type IIA/B
- Key
- Adult and Paediatric Patients (male and female)
- A histologically proven diagnosis of FCDIIA/B or a suspected diagnosis of FCDIIA/B (on MRI/EEG and PET grounds) awaiting resective Epilepsy surgery.
- Able to attend appointment/hospital and undergo sampling of serum and nasal swab
- Informed Consent Available
- Key
Exclusion
- Any acute or chronic conditions that could limit the ability of the patient to participate in the study.
- Refusal to give informed consent.
Key Trial Info
Start Date :
April 9 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 8 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06053671
Start Date
April 9 2023
End Date
April 8 2026
Last Update
October 23 2024
Active Locations (1)
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1
King's College Hospital
London, United Kingdom