Status:
RECRUITING
Somatic Mosaicism in Twins Discordant for Childhood Cancer
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Pediatric Central Nervous System Tumor
Central Nervous System Tumor
Eligibility:
All Genders
Up to 18 years
Brief Summary
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with centra...
Detailed Description
PRIMARY OBJECTIVES: I. To conduct a descriptive study of same sex twins (MZ and DZ) discordant for childhood CNS tumors identified through the Children's Oncology Group Project:EveryChild registry. ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
- Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
- Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
- A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
- All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
- All institutional, FDA, and NCI requirements for human studies must be met.
Exclusion
Key Trial Info
Start Date :
June 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06054295
Start Date
June 3 2024
End Date
June 30 2027
Last Update
December 16 2025
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455