Status:
UNKNOWN
Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Acute Ischemic Stroke
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillati...
Detailed Description
Anticoagulation therapy is effective to prevent ischemic stroke in patients with NVAF who have a history of stroke. Recent clinical trials have demonstrated that early initiation of anticoagulation th...
Eligibility Criteria
Inclusion
- Age \> 18 years old
- Acute ischemic stroke with onset \< 48 hours
- Have a history or newly diagnosed as NVAF
- NIHSS on admission \<= 8
Exclusion
- Chronic renal dysfunction (GFR \< 30ml/min) or severe hepatic injury
- Have a history or newly diagnosed as valvular heart disease
- Mural thrombus in heart
- Contraindications of anticoagulation therapy within 12 days after AIS, e.g. severe intracranial hemorrhage
- Received reperfusion therapy, e.g. intravenous thrombolysis and endovascular treatment
- Concomitant stenosis (\>50%) of carotid artery/intracranial artery, of which the ischemic lesion located within the territory
- Life expectancy less than 1 year
- Plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding
- Pregnant or lactating women
- Individuals identified by researchers as unsuitable for participation in the study due to other reasons.
Key Trial Info
Start Date :
September 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
2351 Patients enrolled
Trial Details
Trial ID
NCT06057467
Start Date
September 15 2023
End Date
January 1 2026
Last Update
March 18 2024
Active Locations (2)
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1
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, China
2
Jiaxing Second Hospital
Jiaxing, China