Status:
RECRUITING
Tranexamic Acid in Nasal Mohs Reconstruction
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Postoperative Bleeding
Skin Cancer Face
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
Detailed Description
Tranexamic acid (TXA) is an antifibrinolytic agent that acts to decrease bleeding by stabilizing the fibrin matrix involved in the clotting cascade. The use of TXA has been extensively described in th...
Eligibility Criteria
Inclusion
- Adults at least 18 years of age undergoing local flap reconstruction (bilobe flap, note flap dorsal nasal flap, advancement flap) of a nasal defect following Mohs micrographic surgery. Reconstructive procedures will be performed by Drs. Yang or Patel in the division of Facial Plastic Surgery in the Department of Otolaryngology, Head and Neck Surgery at Vanderbilt University Medical Center.
- No other facial plastic procedure or sinus surgery performed simultaneously.
- Lack of all the below exclusion criteria.
Exclusion
- Known allergy to TXA
- Intracranial bleeding
- Known defective color vision
- History of venous or arterial thromboembolism
- History of coagulation disorder
- Active thromboembolic disease
- Severe renal impairment (diagnosis of chronic kidney disease)
- History of acute myocardial infarction
- History of stroke
- History of seizure
- History of liver failure
- Preoperative lab results indicating thrombocytopenia (platelets \<150,000), increased bleeding risk (PT over 45, INR over 1.2).
Key Trial Info
Start Date :
March 19 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06057675
Start Date
March 19 2024
End Date
June 1 2026
Last Update
August 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232