Status:
RECRUITING
Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Cystic Fibrosis Foundation
Conditions:
Cystic Fibrosis
Ventilatory Defect
Eligibility:
All Genders
18-99 years
Brief Summary
The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measur...
Eligibility Criteria
Inclusion
- Subjects must be ≥18 years of age
- Non-smokers (\<10 pack/year history and no active smoking in the past year)
- Diagnosis of cystic fibrosis via standard sweat chloride/phenotypic features/genotyping
- No use of supplemental oxygen
- Stable lung function (within 10% of personal best in the last 6 months) with no pulmonary exacerbations in the past 4 weeks and baseline FEV1≥60% of predicted
- Evidence of a personally signed and dated consent indicating that the subject has been informed of all pertinent aspects of the trial
- Subjects must be willing and able to comply with scheduled visits and other trial procedures
Exclusion
- Subjects presenting with any of the following will not be included in the trial:
- Active or past smokers or vapers with less than 1 year since quitting or \>10 pack-year smoking history
- Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications including
- Occupation (past or present) of machinist, welder, or grinder;
- Injury to the eye involving a metallic object
- Injury to the body by a metallic object (bullet, bullet ball, shrapnel)
- Presence of a cardiac pacemaker or defibrillator
- Presence of aneurysm clips
- Presence of carotid artery vascular clamp
- Presence of neurostimulator
- Presence of insulin or infusion pump
- Presence of implanted drug infusion device that is not known to be MRI compatible (i.e., was placed outside of UNC or is older than 10 years)
- Bone growth or fusion simulator
- Presence of cochlear, otologic or ear implant
- Any type of prosthesis (eye, penile, etc.)
- Artificial limb or joint
- Non-removable electrodes (on body, head or brain)
- Intravascular stents, filters or coils
- Shunt (spinal or intraventricular)
- Swan-Ganz catheter
- Any implant held in place by a magnet
- Transdermal delivery system (e.g. Nitro)
- An intrauterine device or diaphragm that is not MRI compatible
- Tattooed makeup (eyeliner, lips, etc.) or tattoos covering \>25% of body surface area
- Body piercings (must be removed before MRI)
- Any metal fragments
- Internal pacing wires
- Metal or wire mesh implants
- Hearing aid (remove before MRI) aa. Dentures (remove before MRI) bb. Claustrophobia
- Unable to tolerate inhalation of gas mixture
- Presence of facial hair that may interfere with the fit of the mask (and unwillingness to shave prior to each MRI)
- Any changes in medications that may affect CF lung disease in the past 28 days, including any experimental therapies
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
- Pregnancy; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.
Key Trial Info
Start Date :
January 20 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06057714
Start Date
January 20 2021
End Date
December 1 2025
Last Update
October 29 2025
Active Locations (1)
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1
Univeristy of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514