Status:
UNKNOWN
Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Acute Ischemic Stroke
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to compare the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (AIS) patients with concomitant non-valvular a...
Detailed Description
Concomitant NVAF and extracranial/intracranial artery stenosis will greatly increase the risk of stroke, even with standard anticoagulation. However, clinicians may be concerned with the high risk of ...
Eligibility Criteria
Inclusion
- Age \> 18 years old
- Acute ischemic stroke or TIA with onset \< 7 days
- Have a history or newly diagnosed as NVAF
- Concomitant stenosis (\>50%) of carotid artery/intracranial artery, of which the ischemic lesion located within the territory
Exclusion
- Chronic renal dysfunction (GFR \< 30ml/min) or severe hepatic injury
- Have a history or newly diagnosed as valvular heart disease
- Mural thrombus in heart
- Contraindications of anticoagulation or antiplatelet therapy, e.g. severe intracranial hemorrhage
- Myocardial infarction within 6 months before enrollment or received percutaneous coronary intervention in the past
- Have or plan to receive CEA or CAS in the following 3 months
- Life expectancy less than 1 year
- Plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding
- Pregnant or lactating women
- Individuals identified by researchers as unsuitable for participation in the study due to other reasons.
Key Trial Info
Start Date :
September 29 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
2171 Patients enrolled
Trial Details
Trial ID
NCT06058130
Start Date
September 29 2023
End Date
January 1 2026
Last Update
March 18 2024
Active Locations (2)
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1
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, China
2
Jiaxing Second Hospital
Jiaxing, China