Status:
COMPLETED
Predictors of AIS Unfavorable Outcomes
Lead Sponsor:
Kafrelsheikh University
Conditions:
Ischemic Stroke
Alteplase Adverse Reaction
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors were predictive variables for unfavourable outcomes.
Detailed Description
Investigators conducted a prospective cohort study between January 2022 and June 2023 and screened 1184 patients presented with AIS and received alteplase and included 592 AIS patients who met the inc...
Eligibility Criteria
Inclusion
- The investigators enrolled individuals of both genders, aged between 18 and 75, who presented with acute first-ever ischemic stroke and were eligible for thrombolysis.
Exclusion
- The investigators excluded patients who had not been followed up on for 90 days after enrollment,
- Those with alteplase contraindications or did not receive the total dose of alteplase due to any reason were excluded
- The investigators excluded patients with a known history of persistent or recurrent CNS pathology (e.g., epilepsy, meningioma, multiple sclerosis, history of head trauma with a residual neurological deficit).
- The investigators excluded patients who had recurrent ischemic stroke diagnosed by appropriate clinical history and/or MRI brain findings.
- The investigators excluded patients with symptoms of major organ failure, active malignancies, or an acute myocardial infarction within the previous six weeks.
- The investigators also excluded pregnant and lactating patients with stroke due to venous thrombosis and stroke following cardiac arrest.
Key Trial Info
Start Date :
January 3 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 29 2023
Estimated Enrollment :
592 Patients enrolled
Trial Details
Trial ID
NCT06058884
Start Date
January 3 2022
End Date
June 29 2023
Last Update
October 10 2023
Active Locations (1)
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1
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt, 33511