Status:
RECRUITING
Magnetic Resonance Imaging (MRI) and Eye-tracking Predictive Markers of Cognitive Ageing.
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Aging
Eligibility:
All Genders
60-100 years
Phase:
NA
Brief Summary
This research proposes to investigate physiological and cognitive markers of locus coeruleus (LC) neuronal integrity and function in cognitively-healthy participants over 60 years old. The locus coeru...
Detailed Description
The LC is a small brainstem nucleus, sole source of noradrenaline (NA) to the brain. NA is involved in the physiological arousal response: LC neuronal activity is closely related with pupil dilation, ...
Eligibility Criteria
Inclusion
- INSPIRE cohort participant
- Mini-Mental State Examination score ≥ 27 on 30
- Access to a web connection from participant's or relative's home and regular use of web surfing
- Signature of the informed consent
- Affiliated to a social security scheme
Exclusion
- Any contra-indications to MRI exam
- Ophthalmic pathology impacting eye-tracking measures
- Neurological or psychiatric pathology
- Person under guardianship or curatorship
- Contraindications to MRI examination:
- Pacemaker or cardiac defibrillator
- Implanted material activated by an electrical, magnetic or mechanical system
- Haemostatic clips for intracerebral aneurysms or carotid arteries
- Orthopedic implants
- Claustrophobia
- Ophthalmological pathologies impacting eye tracking measurements:
- Glaucoma
- Age-related macular degeneration
- Unoperated cataract
Key Trial Info
Start Date :
March 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 22 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06058897
Start Date
March 22 2024
End Date
March 22 2028
Last Update
December 22 2025
Active Locations (1)
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1
University Hospital
Toulouse, France, 31059