Status:
UNKNOWN
Pathological Changes in the Cardiovascular System in Valvular Heart Disease
Lead Sponsor:
University College, London
Collaborating Sponsors:
British Heart Foundation
Horizon 2020 - European Commission
Conditions:
Valvular Heart Disease
Eligibility:
All Genders
18+ years
Brief Summary
An observational cohort study of patients recruited presenting with valvular heart disease. The specialized investigations will focus on myocardial remodelling and scar formation/regression and extrac...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Able to provide written informed consent
- Mild, moderate or severe valvular heart disease (Natural history cohort), or severe valvular heart disease planned for surgical/transcatheter intervention (Intervention/Heart-Brain axis cohort).
Exclusion
- Participants unwilling to consent.
- Needle phobic patients that would preclude blood taking
- Diagnosis of dilated or hypertrophic cardiomyopathy
- Pregnancy/breast feeding
- Inability to complete the protocol, other conditions that would prevent participation in the study.
- In severe VHD, no more than moderate valve disease other than primary lesion (AS / MR / AR)
- Exclusion for the Heart-Brain-Axis Study:
- • Participants that have more than moderate epicardial coronary disease (by CT or invasive coronary angiography) will be excluded.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT06060171
Start Date
August 1 2021
End Date
January 1 2025
Last Update
October 6 2023
Active Locations (1)
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1
Barts Heart Centre
London, United Kingdom, EC1A 7BE