Status:
RECRUITING
Effect of Timed-Restricted Eating on Metabolic Health
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
Diabetesfonds
Conditions:
Obesity
Non-Alcoholic Fatty Liver Disease
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subje...
Detailed Description
Obesity is an alarming global health issue, with increasing prevalence. Obesity leads to a vast array of disorders, including dyslipidemia, the accumulation of intrahepatic triglycerides (IHTG), multi...
Eligibility Criteria
Inclusion
- Ability to provide informed consent;
- BMI \> 30kg/m\^2;
- Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
- Stable weight for 3 months prior to study inclusion
- For women, 1 year after last menstrual cycle
Exclusion
- Use of any medication, except for those related to treatment of metabolic syndrome;
- Any medical condition interfering with study outcomes or design;
- History of any psychiatric disorder, including eating disorders;
- Performing shift work
- Performing intensive sports (\>3 hours/week);
- Smoking;
- Drugs abuse or alcohol abuse (\>3 units/day);
- Contraindication for MRI;
- Known lactose/gluten intolerance;
- Known soy, egg, milk or peanut allergy;
- Childhood onset of obesity
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06061042
Start Date
October 1 2023
End Date
December 1 2027
Last Update
September 29 2023
Active Locations (1)
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1
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105AZ