Status:
NOT_YET_RECRUITING
Quantitative MRI For Detection and Tracking of Knee Osteoarthritis
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Imperial College Healthcare NHS Trust
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
40-70 years
Brief Summary
The goal of this observational study is to develop whole-joint quantitative MRI techniques that aid in the detection and tracking of osteoarthritis disease progression at 3T and 7T MRI scanners. The r...
Eligibility Criteria
Inclusion
- Inclusion Criteria For Healthy Volunteers:
- All people between 40 to 70 years of age
- All people with no history of knee injury, surgery, or knee pain
- Exclusion Criteria For Healthy Volunteers:
- Patients with body mass index of more than 35, or body geometry that prevents scanning due to MRI scanner bore width or knee coil diameter
- Patients with varus or valgus malalignment
- Patients with contraindications to MRI
- Patients lacking capacity to consent
- Patients who are pregnant or breast-feeding
- Patients who are participating in a clinical trial(s) for new drugs and/or therapies
- Inclusion Criteria for Knee Osteoarthritis Patients:
- All patients with primary osteoarthritis (grade 2-3 per Kellgren-Lawrence Scale)
- Patients who have had radiographs taken as part of their routine clinical care agreed with their orthopaedic surgeon, Mr Gareth Jones. Note that their radiographs must have been acquired a maximum of three weeks from the first, baseline scanning session. This radiograph will be used to check if patients have primary osteoarthritis.
- All patients between 40 to 70 years of age
- Exclusion Criteria for Knee Osteoarthritis Patients
- Patients with body mass index of more than 35, or body geometry that prevents scanning due to MRI scanner bore width or knee coil diameter
- Patients with varus or valgus malalignment of more than 5°
- Patients with radiographic osteoarthritis (grade ≥4 per Kellgren-Lawrence Scale, obtained from radiographs)
- Patients with contraindications to MRI
- Patients lacking capacity to consent
- Patients who are pregnant or breast-feeding
- Patients who are participating in a clinical trial(s) for new drugs and/or therapies
Exclusion
Key Trial Info
Start Date :
October 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06063304
Start Date
October 1 2023
End Date
September 1 2026
Last Update
October 2 2023
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.