Status:
RECRUITING
Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
Lead Sponsor:
Jena University Hospital
Conditions:
Cardiac Valve Disease
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what ...
Detailed Description
In the course of a myocardial infarction, the death of cardiomyocytes leads to the release of specific cardiac biomarkers (CK-MB, troponin I and T). Since there is a general risk of perioperative infa...
Eligibility Criteria
Inclusion
- Indication for isolated aortic or mitral valve surgery
- Written informed consent
- Age ≥ 18 years
Exclusion
- Presence of coronary artery disease (excluded within the last 6 months)
- Allergy to gadolinium
- Cochlear implant
- Deep brain stimulation
- Individual factors excluding the performance of an MRI (e.g. claustrophobia of the patient)
- Significantly reduced renal function (GFR \< 30ml/min)
- Perioperative complications that may lead to myocardial damage (discontinuation of the study for the patient and exclusion from the analysis after primary study inclusion)
- Need for extension of surgery (additional procedures on other heart valves, aorta, myocardium, or similar; exclusion after primary study inclusion possible)
- Pregnancy or lactation
Key Trial Info
Start Date :
September 5 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06066970
Start Date
September 5 2023
End Date
December 31 2025
Last Update
September 26 2025
Active Locations (5)
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1
Universitäts-Herzzentrum Freiburg • Bad Krozingen
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106
2
Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, Germany, 89081
3
Universitätsklinikum Münster
Münster, North Rhine-Westphalia, Germany, 48149
4
Universitätsklinikum Halle
Halle, Saxony-Anhalt, Germany, 06120