Status:
RECRUITING
Effect of MOPs During Orthodontic Movement in Periodontitis Patients
Lead Sponsor:
Universidad Complutense de Madrid
Conditions:
Stage IV Periodontitis
Orthodontic Tooth Movement
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associat...
Detailed Description
This is a comparative 2-arm parallel single-blinded randomized controlled clinical trial, with allocation ratio of 1:1, aimed to test an intervention (the use of MOPs) on CAL changes 12 months after p...
Eligibility Criteria
Inclusion
- Patients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:
- adult patients older than 18-year-old;
- systemically healthy (see exclusion criteria);
- diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;
- the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \<5mm) (experimental teeth);
- in need of orthodontic therapy.
Exclusion
- systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);
- any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);
- pregnant or lactating woman;
- inability to respond questions or to attend follow-up visits;
- extreme skeletal malocclusions requiring orthognathic surgery;
- patients smoking more than 10 cigarettes/day; and
- the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy
Key Trial Info
Start Date :
December 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT06068270
Start Date
December 15 2023
End Date
January 1 2026
Last Update
March 27 2025
Active Locations (1)
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1
Faculty of Odontology, University Complutense Madrid
Madrid, Madrid, Spain, 28040