Status:
UNKNOWN
Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Acute on Chronic Liver Failure
Eligibility:
All Genders
18-70 years
Brief Summary
Acute-on-chronic liver failure (ACLF) is a syndrome associated with a high short- term mortality. Early identification of patients at high risk is important to determine emergency for transplantation ...
Detailed Description
Study Design 1 year prospective cohort study Hypothesis: We hypothesize that acute change in liver and splenic stiffness at 7th \& 14 th day predicts outcome in ACLF patients Aim and Objective - Prim...
Eligibility Criteria
Inclusion
- Patients of ACLF as per APASL criteria between 18 to 70 years of age
- Patient and attendants willing to give informed consent
Exclusion
- Age \<18 years and \> 70 years
- Survival less than 7 days
- Cirrhosis with prior decompensation
- Grade 3 ascites
- Hepatic encephalopathy grade III \&IV
- HCC/SOL \>2cm in liver
- Patient with congestive heart failure
- Patient with extrahepatic cholestasis
- Portal vein thrombosis
- BMI \>30 kg/m2
- Prior variceal endotherapy or ongoing beta blocker treatment for varices
- Pregnant and lactating women
- Patient with cardiac pacemaker
- Critically ill patients
Key Trial Info
Start Date :
September 25 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06069284
Start Date
September 25 2023
End Date
September 30 2024
Last Update
October 5 2023
Active Locations (1)
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1
Institute of Liver & Biliary Sciences
New Delhi, India, 110070