Status:
UNKNOWN
The MASTER-PACT Study
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Microvascular Coronary Artery Disease
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Brief Summary
The goal of this clinical trial is to compare non-invasive myocardial perfusion reserve (MRR) to invasively measured MRR in patients suspected for coronary artery disease (CAD). The main question it ...
Detailed Description
Rationale: In at least 25% - 50% of patients with chest pain, myocardial ischemia can be present without angiographic evidence of significant epicardial disease. In such patients, it is often assumed...
Eligibility Criteria
Inclusion
- Referred for ICA because of suspected CAD
- No documented prior history of CAD
- Age ≥18 and ≤80 years old
Exclusion
- Unstable CAD, Non-ST-Elevation Myocardial Infarction (NSTEMI), ST-Elevation Myocardial Infarction (STEMI), cardiogenic shock or hemodynamically unstable patients
- Patients with previous coronary artery bypass (CABG) surgery, PCI or myocardial infarction (MI)
- Tortuous or calcified coronary arteries, if known
- Coronary arteries with a small caliber (\<2,5 mm), if known
- Atrial fibrillation, second or third degree atrioventricular block or severe conduction disturbances with an indication for temporary or permanent pacing
- History of severe COPD or chronic asthma
- Renal failure ( i.e. eGFR \< 30 mL/min)
- Use of sildenafil (Viagra) or dipyramidol (Persantin) that cannot be terminated
- Contra-indications for β-blockers
- Allergic reaction to iodized contrast
- Pregnancy
- Inability to understand and give informed consent
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06069401
Start Date
January 1 2024
End Date
July 1 2025
Last Update
October 5 2023
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