Status:
RECRUITING
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
Lead Sponsor:
Yale University
Collaborating Sponsors:
VA Connecticut Healthcare System
National Headache Foundation
Conditions:
Post-Traumatic Headache
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will ...
Detailed Description
Military Servicemembers are at elevated risk for traumatic brain injury (TBI) and its consequences, including post-traumatic headache (PTH). The most common phenotype of PTH is migraine, for which the...
Eligibility Criteria
Inclusion
- United States Military Veterans within VA Connecticut Healthcare System
- Chronic post-traumatic headache per ICHD-3 criteria (i.e., headaches are continuing to occur three months after the head injury)
- At least two headache days per week
- MRI brain scan completed within the past 3 months if chronic PTH for less than one year, within the past year if chronic PTH for less than 5 years, and within 5 years if chronic PTH for more than 10 years
- Review of MRI and the medical record does not reveal another source for headache
Exclusion
- Skull defect
- Other contraindication to bupivacaine
- Allergy or adverse reaction (e.g., rash, cardiac effects) to amide anesthetics, such as lidocaine
- Instruction from clinician to avoid amide anesthetics, such as lidocaine
- Pregnant or lack of adequate birth control
Key Trial Info
Start Date :
January 26 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06069791
Start Date
January 26 2024
End Date
September 30 2025
Last Update
March 17 2025
Active Locations (1)
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1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516