Status:
RECRUITING
Non-invasive Diagnosis of Coronary Microvascular Disease: Pilot Study
Lead Sponsor:
University of Leicester
Conditions:
Microvascular Angina
Eligibility:
All Genders
18+ years
Brief Summary
* 40% of patients presenting with stable chest pain (angina) have no significant blockage of the main heart arteries. Identifying why these patients have symptoms will mean better treatment options ca...
Detailed Description
* Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the United Kingdom. Approximately 40% of patients presenting with angina, however, have no evidence of significant ob...
Eligibility Criteria
Inclusion
- Current participant of the 'CMR versus CT-FFR in CAD' study
- Continue to meet the inclusion criteria for the main study:
- Patients aged ≥18 years
- Referred for invasive coronary angiography for investigation of chest pain
- Willing and able to give informed consent
- Willing and able (in the Investigators opinion) to comply with all study requirements.
- Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
- Able to understand written English
- Able to perform exercise in the MRI scanner
- Study arm:
- No evidence of obstructive or non-obstructive CAD on research CTCA
- Myocardial perfusion defect detected on adenosine stress CMR indicative of CMD
- Control arm:
- • Evidence of multivessel CAD on research CTCA
Exclusion
- Meet the exclusion criteria for the main study:
- Recent acute coronary syndrome (\< 6 months)
- Severe claustrophobia
- Absolute contraindications to CMR - those with MR conditional or safe devices will be included
- Second-/third-degree atrioventricular block
- Severe chronic obstructive pulmonary disease
- Moderate-severe asthma
- Estimated glomerular filtration rate \<30 ml/min/1.73m2
- Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women)
- Contraindication to iodinated contrast
- Participants who have participated in a research study involving an investigational product in the past 12 weeks
- Patients unable to understand written English
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06070662
Start Date
November 1 2023
End Date
December 1 2025
Last Update
December 5 2024
Active Locations (1)
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1
Glenfield Hospital, University Hospitals of Leicester
Leicester, Leicestershire, United Kingdom