Status:
RECRUITING
The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans
Lead Sponsor:
Rutgers, The State University of New Jersey
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Memory, Short-Term
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disor...
Eligibility Criteria
Inclusion
- Has seizure activity which is deemed non-responsive to standard pharmacological intervention(s), as determined by treating Neurologist and established clinical practices
- Has elected to receive clinically indicated intracranial EEG (electrocorticography (ECoG), stereoelectroencephalography (SEEG)) and/or temporal responsive neurostimulation (RNS) for medication-refractory epilepsy outside of this research study, as determined by treating clinician(s) and per current clinical practice
- Capacity to provide written informed consent
- Language proficiency in English or Spanish
- Willing and able to comply with all study-related procedures
Exclusion
- History of psychosis, such as in the context of depressive or manic episode.
- Active suicidal ideation with intent, suicide attempt within the last six months, or other serious suicide risk
- Inability to provide informed consent or reliably participate in study assessments, as per the Montreal Cognitive Assessment (MOCA; score \< 26) or in the opinion of the evaluating neuropsychologist.
- Individuals unwilling or unable to undergo electrode implantation procedures
- Medical contraindications to neurosurgery or for general anesthesia, neurosurgery, or an MRI scan (required for electrode implantation)
- Neurological disorder other than epilepsy or other significant brain pathology, if contraindicated in the opinion of implanting neurosurgeon.
- Women who are pregnant
Key Trial Info
Start Date :
October 31 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2028
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06072378
Start Date
October 31 2023
End Date
September 1 2028
Last Update
December 17 2025
Active Locations (1)
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1
Rutgers Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States, 08901