Status:
COMPLETED
OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
Lead Sponsor:
University of Palermo
Conditions:
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Eligibility:
All Genders
18-99 years
Phase:
PHASE1
PHASE2
Brief Summary
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition. Today, no sp...
Detailed Description
The enrolled patients were randomly divided into two groups: Group A: consisting of 38 patients (undergoing ozone treatment) (OZONE\_EXO) intra-tissutal perialveolar injections of a 15-mL mixture of ...
Eligibility Criteria
Inclusion
- age ≥ 18 yrs
- patients at risk of developing MRONJ for previous or current administration of drugs related
- extraction of teeth with a poor prognosis due to severe decay and/or periodontitis
Exclusion
- previous radiation in the head and neck area
- neoplastic involvement of the jaw
- previous MRONJ diagnosis
Key Trial Info
Start Date :
February 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2020
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT06072404
Start Date
February 1 2018
End Date
March 30 2020
Last Update
January 9 2025
Active Locations (1)
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1
Azienda Ospedaliera Universitaria Policlinico "P. Giaccone" Palermo
Palermo, Italy, 90127