Status:
UNKNOWN
Portable Continuous Positive Airways Pressure (CPAP) in Excessive Central Airway Collapse (ECAC) Study
Lead Sponsor:
Papworth Hospital NHS Foundation Trust
Conditions:
Excessive Central Airways Collapse
Respiratory Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will investigate the role of a portable Continues Positive Airway Pressure device (pCPAP) in management of patients with symptomatic Excessive Central Airway Collapse (ECAC). ECAC is charac...
Eligibility Criteria
Inclusion
- Diagnosis of ECAC based on \>50% reduction of the antero-posterior diameter of large airways demonstrated on dynamic CT thorax or bronchoscopy. Only patients with tracheal and/or bilateral large bronchi (main to lobar) involvement will be included.
- Symptoms of dyspnoea felt to be predominantly caused by ECAC (where ECAC is the only respiratory pathology or dyspnoea is clearly out of proportion to a co-morbid respiratory condition)
- Medical Research Council (MRC) breathlessness scale of 3 (I stop for breath after walking about 100 yards or after a few minutes on level ground) or more.
- Age over 18 years
- Able to give informed consent -
Exclusion
- Patients with dynamic collapse of only segmental airways
- Comorbidity which is likely to be an additional limiting factor in exercise tolerance
- Contraindication to CPAP
- Contraindication to incremental shuttle walk testing (ISWT), including; myocardial infarction within the last 3-5 days, unstable angina, uncontrolled arrhythmia, severe symptomatic cardiac or valvular disease, acute pulmonary embolus, uncontrolled asthma, syncope, mental impairment resulting in inability to perform test.
- Resting oxygen saturations \<90% on air or need for ambulatory oxygen therapy
- Immobility that would make ISWT unfeasible
- Severe emphysema
- Acute infectious disease
- Acute respiratory illness
Key Trial Info
Start Date :
July 27 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06072872
Start Date
July 27 2023
End Date
July 31 2024
Last Update
October 10 2023
Active Locations (1)
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1
Royal Papworth Hospital
Cambridge, Cambridgeshire, United Kingdom, CB2 0AY