Status:
RECRUITING
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
Lead Sponsor:
Tan Tock Seng Hospital
Collaborating Sponsors:
Rehabilitation Research Institute of Singapore (RRIS)
Woodlands Health (WH)
Conditions:
Stroke
Traumatic Brain Injury
Eligibility:
All Genders
50+ years
Brief Summary
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data ...
Detailed Description
Osteosarcopaenia and multimorbidity have emerged as two key antecedent factors driving the cycle of frailty, leading to adverse outcomes. However, it remains unclear how multimorbidity and/or osteosar...
Eligibility Criteria
Inclusion
- Age ≥ 50y
- Asian ethnicity
- First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)
- Living in community
- Able to understand 1 step simple commands
- For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission
- For outpatients: (i) \>6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking.
Exclusion
- Nursing home or dormitory resident
- Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)
- Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,
- Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium
- Anticipated life expectancy \< 1 year
- Presence of tracheostomy, ventilator, renal dialysis, end-organ failure
- Patients with disorders of consciousness.
- Pregnant or lactating participants
- For Knee Osteoarthritis patients only:
- Alternative diagnosis to knee OA e.g. Referred pain from hip or spine.
- Other forms of knee arthritis eg. Inflammatory, post traumatic
- Previous knee arthroplasty
Key Trial Info
Start Date :
January 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06073106
Start Date
January 1 2025
End Date
January 1 2027
Last Update
April 11 2025
Active Locations (1)
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1
Tan Tock Seng Hospital
Singapore, Singapore, Singapore, 308433