Status:
RECRUITING
Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Methylphenidate
Metabolomics
Eligibility:
All Genders
6-18 years
Brief Summary
To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects o...
Detailed Description
Although the efficacy of methylphenidate in reducing the core symptoms of attentiondeficit/ hyperactivity disorder (ADHD) is well documented in clinical trials, no definite biomarker has been identifi...
Eligibility Criteria
Inclusion
- Patients with ADHD
- Inclusion Criteria
- Patients, aged 6 to 18 years, meet the DSM-5 diagnostic criteria for ADHD.
- At baseline, patients have a Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) score greater than 4.
- Patients have a Full IQ (FIQ) score greater than 80.
- Exclusion Criteria
- Patients have a major psychiatric disorder, such as autism spectrum disorder, schizophrenia, affective disorders, or substance use disorders.
- Patients have a major disorder of central nervous system, such as epilepsy.
- Patients have a major systemic disease, such as diabetes mellitus or cardiovascular diseases.
- Patients have ever received any medication to treat the clinical symptoms of ADHD.
- Neurotypical participants:
- Inclusion Criteria
- aged 6 to 18 years
- All of the neurotypical participants have no psychiatric disorder in lifetime according to the diagnostic criteria of DSM-5.
- Exclusion Criteria
- participants have any disorder of central nervous system or major systemic disease
- participants have ever taken any psychotropic drug, or who have FIQ scores less than 80, will be excluded from the present study.
Exclusion
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06073470
Start Date
January 1 2024
End Date
December 31 2027
Last Update
March 26 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Taiwan University Hospital
Taipei, Taiwan, 110