Status:
RECRUITING
Total Lymphoid Irradiation as Conditioning for Pediatric Haploidentical Hematopoietic Stem Cell Transplantation
Lead Sponsor:
Hong Kong Children's Hospital
Collaborating Sponsors:
The University of Hong Kong
Hong Kong Sanatorium & Hospital
Conditions:
Hematopoietic Organs; Disorder
Eligibility:
All Genders
Up to 18 years
Phase:
NA
Brief Summary
In this comparative study, the investigators aim to compare prospective pediatric patients who receive total lymphoid irradiation (TLI) using tomotherapy with age- and disease-matched controls who rec...
Detailed Description
Radiotherapy at a dose of 6Gy divided into 3 equal fractions (2Gy per fraction) to all lymphoid organs (TLI) over 2 days using tomotherapy will be given to participants as part of the conditioning tre...
Eligibility Criteria
Inclusion
- Aged 0-18 years who requires allogeneic HSCT, has no human leukocyte antigen (HLA)-matched sibling donor but has an HLA-haploidentical donor.
- Adequate organ function to tolerate the conditioning chemotherapy and radiotherapy
- Karnofsky or Lansky performance status score ≥50
Exclusion
- Pregnant or lactating woman
- HIV infection
- Patients for whom alternative treatment is deemed more appropriate by treating physician
- Patients who are unlikely to benefit from haploidentical hematopoietic stem cell transplantation, e.g., terminal malignancy with multiorgan failure
Key Trial Info
Start Date :
May 29 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT06075563
Start Date
May 29 2023
End Date
December 1 2026
Last Update
September 10 2025
Active Locations (1)
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1
Hong Kong Children's Hospital
Hong Kong, Hong Kong