Status:
UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases
Lead Sponsor:
Marmara University
Conditions:
Periodontal Diseases
Gingivitis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The present study aimed to assess the effect of non-surgical periodontal treatment on serum and salivary IL-1beta, IL-18, NLRP3, ASC and Caspase-1 levels in gingivitis and Stage III Grade C periodonti...
Detailed Description
New insights into the first line of immune response to infection and stress signals at the cellular level have reported the participation of cytoplasmic nucleotide-binding domain-like receptors contai...
Eligibility Criteria
Inclusion
- systemically healthy and non-smoker individuals
- having ≥20 teeth present (except third molars)
- individuals with periodontally healthy, gingivitis or stage III grade C periodontitis diagnoses
Exclusion
- having any diagnosed medical disorders such as diabetes mellitus, cardiovascular diseases, rheumatoid arthritis...
- usage of antibiotics, non-steroidal anti-inflammatory drugs and immunosuppressive agents within the past 6 months.
- periodontal treatment within the preceding 6 months.
- pregnant/ lactating/ postmenopausal females.
- Current orthodontic treatment.
Key Trial Info
Start Date :
March 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2023
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06075680
Start Date
March 4 2022
End Date
November 1 2023
Last Update
October 10 2023
Active Locations (1)
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1
Marmara University
Istanbul, Maltepe, Turkey (Türkiye), 34854