Status:
RECRUITING
Correlation Between Microbial Infection and Lumbar Degenerative Disease Based on High-throughput Gene Sequencing
Lead Sponsor:
HaoxuanZhang
Conditions:
Lumbar Degenerative Diseases
Gene Product Sequence Variation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Lumbar degenerative disease is one of the most common diseases in orthopedic and spinal surgery. The pathogenesis of lumbar degenerative disease is still unclear, mainly including aging degeneration a...
Detailed Description
This study intends to use the high-throughput gene sequencing technology of infectious pathogens based on nano single molecule sequencing, double verification of blood samples and intervertebral disc ...
Eligibility Criteria
Inclusion
- Patients in the experimental group, aged 18 to 85 years old, have symptoms and imaging data that support the diagnosis of lumbar degenerative diseases (including lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis).
- Patients who undergo strict conservative treatment for 3 months before surgery have no significant improvement in symptoms; The control group of patients had no significant lumbar disc degeneration evaluated by imaging, but needed surgical decompression and fusion intervention due to trauma causing lumbar fractures, lumbar tumors, scoliosis.
- The disc organizer can be obtained during surgery.
Exclusion
- Lumbar degenerative diseases combined with infectious diseases.
- Lumbar degenerative diseases combined with mental diseases.
- Lumbar degenerative diseases combined with metal allergy.
Key Trial Info
Start Date :
January 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06075979
Start Date
January 2 2020
End Date
December 31 2027
Last Update
January 22 2025
Active Locations (1)
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1
Hao-Xuan Zhang
Jinan, Shandong, China, 250000