Status:
RECRUITING
A Retrospective Study on the Relationship Between Donor Leukocyte Telomere Length and Prognosis of Acute Leukemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation
Lead Sponsor:
Zhejiang University
Conditions:
Acute Leukemia
Eligibility:
All Genders
5-90 years
Brief Summary
This post hoc analysis included patients with acute leukemia who underwent allo-HSCT at the First Affiliated Hospital of Zhejiang University School of Medicine and Ruijin Hospital Shanghai Jiaotong Un...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age ≥ 5 years
- First allo-HSCT from matched related, unrelated, or haploidentical donors
- Achievement of complete remission after allo-HSCT
- Donor blood sample collection before granulocyte colony-stimulating factor mobilization
- Exclusion Criteria
- Non-acute leukemia diagnoses, including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia
- Failure to achieve engraftment with full donor chimerism after allo-HSCT
- Inability to extract DNA for telomere length analysis.
Exclusion
Key Trial Info
Start Date :
January 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
2500 Patients enrolled
Trial Details
Trial ID
NCT06076226
Start Date
January 1 2015
End Date
December 1 2026
Last Update
October 10 2023
Active Locations (1)
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1
Clinical research ethics committee of the first affiliated hospital, college of medicine, zhejiang University
Hangzhou, Zhejiang, China