Status:
UNKNOWN
Acute Health Effects of Low Temperature Exposure
Lead Sponsor:
Fudan University
Conditions:
Cardiovascular System
Respiratory System
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low temperature exposure and the underlying mechanisms.
Detailed Description
The investigators will conduct a randomized controlled human exposure crossover study among about 50 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temper...
Eligibility Criteria
Inclusion
- Living in Shanghai during the study period;
- Body mass index \> 18.5 and ≤ 28;
- Right-handed;
- Receiving or having received higher education;
- With the ability to read and understand Chinese smoothly.
Exclusion
- Smoking and alcohol abuse;
- Current drug and dietary supplements intake;
- Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;
- Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;
- Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
- Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;
- Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases;
- Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;
- Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65);
- Subjects with color vision disabilities.
Key Trial Info
Start Date :
October 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06076629
Start Date
October 10 2023
End Date
December 31 2024
Last Update
October 11 2023
Active Locations (1)
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1
Department of Environmental Health, School of Public Health, Fudan University
Shanghai, Shanghai Municipality, China, 200032