Status:
COMPLETED
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Lead Sponsor:
Ayah Mohammed Khalil
Conditions:
Septic Shock
Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are...
Detailed Description
Sepsis, inflammatory response to infection, contributes directly or indirectly to mortality in the majority of critically ill patients. An elevated cardiac index and a decreased systemic vascular resi...
Eligibility Criteria
Inclusion
- Age adult ≥ 18 years old.
- The patient fulfills the criteria of septic shock definition:
- Sepsis needs vasopressor therapy.
- Serum lactate level greater than 2 mmol/l (SSC 2016).
- Patient with contractility greater than 40%
Exclusion
- paracetamol hypersensitivity or allergy.
- Acute liver injury or failure
- Childs-Pugh C liver disease
- Heat stroke.
- Malignant hyperthermia.
- Neuroleptic Malignant Syndrome.
- Continous renal replacement therapy.
- Ventricular assist device.
- Around-the-clock scheduled of acetaminophen-containing medications administration or non-steroidal anti-inflammatory drugs.
- Pregnancy/lactation.
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 24 2023
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT06076980
Start Date
November 1 2020
End Date
January 24 2023
Last Update
October 12 2023
Active Locations (1)
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1
Cairo University hospitals
Cairo, Egypt, 11725